A biotechnological product from Silab, Regenixir is an anti-aging active ingredient offering rapid, all-round regeneration for mature skin.
Boosting key regeneration processes
In the event of aggression, several systems (cutaneous, immune, vascular) cooperate to energize the cellular interactions essential to skin regeneration. The fibroblast plays a pivotal role, interconnecting these three systems by secreting a pool of growth factors. These are known as the "fibroblast regenerative complex". Although this dynamic process exists throughout life, original modelling by Silab research has shown that it is altered with age.1.
Silab has developed Regenixir, a regenerating active ingredient that stimulates the skin's ability to synthesize its own growth elixir. By restoring the ability of aged fibroblasts to interact with their environment, the active ingredient enables transversal action on three interconnected systems:
- skin system: matrix remodeling and epidermal renewal are improved2 ;
- vascular system: the formation of a vascular network is restored3 ;
- immune system: the population of pro-regenerative macrophages is boosted.
Improve skin quality
According to Silab, after 21 days of application, Regenixir tested at 2.5% in emulsion showed anti-wrinkle efficacy, significantly reducing crow's feet wrinkles in Caucasian subjects (-10%) and Asian subjects (-6%).
Under the same conditions, tested on Caucasian volunteers, :
- improves the skin's biomechanical properties (firmness: +10%; elasticity: +14%; tone: +25%);
- reduces the visibility of microvessels (-6%) and is effective against dark circles, significantly improving their color (b* parameter: -2.9%);
- significantly restores parameters characteristic of complexion radiance (radiance: +9%; pink color: +15%; olive color: -7%; luminosity: -6%).
All these effects continue after 42 days of treatment and are perceived by the volunteers themselves.
Biotechnological origin
As part of the development of Regenixir, Silab turned its attention to Saccharomyces cerevisiae yeast. Widely used in the food industry, this yeast is also recognized by the medical and scientific community for its many properties: rich in nutrients, ability to stimulate energy production and immune defenses, etc.
Silab has harnessed the health benefits of S. cerevisiae by extracting oligo-β-glucans capable of restoring the interconnectivity of the cutaneous, immune and vascular systems, for a regenerating anti-aging effect.
Regenixir (Saccharomyces cerevisiae Extract) is a patented product, available in aqueous solution (recommended dose: 0.25 to 2.5%) and compliant with biodiversity regulations. This active ingredient has a natural origin content of 99% (ISO 16128) and complies with international cosmetics regulations (Europe, United States, China, Japan, etc.).
1. Through scientific partnerships with two prestigious international research laboratories, Silab has acquired new technological expertise. The internalization of the skills needed to develop innovative vascularized and immune cell models has enabled us to demonstrate in an unprecedented way the depletion of the fibroblast regenerative complex with age, and its deleterious effect on the interactions of aged fibroblasts with the cutaneous, vascular and immune systems.
2. Tested at 1% on aged human fibroblasts, Regenixir significantly restores the migration rate of aged fibroblasts (+97%) and significantly stimulates their differentiation into myofibroblasts (α-SMA synthesis: +40%).
3. With Regenixir at 1%, the aged fibroblast secretome significantly restores the migration speed (+93%) and cohesion (ZO-1: +77%) of aged endothelial cells.
