The smallest and longest-lasting intracellular hyaluronic acid ever developed, according to Givaudan, PrimalHyal UltraReverse has the ability to penetrate skin cells and act at DNA level, tackling most of the key features of aging at its root.
This new active ingredient aims to redefine the "aging well" experience, targeting four of the five main characteristics of aging:
- Epigenetic control - restoration of DNA methylation processes and enhancement of Sirtuin expression and activity, limiting cryptic transcription.
- Genomic instability - amplification of DNA repair mechanisms for healthier skin.
- Telomere attrition - reactivation of telomerase expression and activity, protecting chromosome integrity.
- Loss of proteostasis - stimulating proteasome activity to ensure optimal cellular function.
By targeting these biological pathways, PrimalHyal UltraReverse protects skin not only from chronological aging, but also from environmental stressors (exposome). According to Givaudan, it increases sirtuin 1 by +136% and improves collagen 1 production by +48%, helping to restore skin's youthfulness.
The result? Younger, healthier-looking skin, whose apparent age can be reduced by up to six years, according to the Swiss firm. It also corrects the main signs of aging, including wrinkles and sleep lines, while improving skin firmness, as demonstrated by a diverse, international panel of volunteers.
"Drawing on the expertise of PrimalHyal 50 Life, the strain engineering experts at Alderys have designed PrimalHyal UltraReverse, an ultra-low molecular weight hyaluronic acid of less than 3 kDa that unleashes new biological benefits. Produced by precision fermentation, its impact on the environment is drastically reduced - setting a new benchmark for sustainable, high-performance skincare."explains Romain Reynaud, Research & Development Manager.
"Longevity has become a key trend in the beauty industry, driven by growing consumer interest in prevention and a holistic approach to skin health. In fact, 84 % of people agree that they should embrace their age rather than trying to hide it, underlining the move towards a more authentic perspective on aging. Givaudan Active Beauty emphasizes that true skincare is not just about appearance, but about longevity, prevention and well-being, offering solutions that preserve the skin's health capital."comments Mathias Fleury, Category Manager - Active Ingredients.
