Probiolift: the first cosmetic ingredient containing a live probiotic helps give skin a fuller appearance and improve the appearance of forehead wrinkles.
Postbiolift: Postbiotic makes the skin more elastic, smoothes the appearance of crow's feet wrinkles and gives the impression of an even skin tone.
The cosmetic ingredients exploit the Lactobacillus crispatus bacteria which are abundant in young skin and considerably diminished in older skin
With Probiolift and Postbiolift, Care Creations from BASF introduces two new biotic ingredients that promote healthy and harmonious aging of the skin. Unlike other biotics on the cosmetic market, the newly developed ingredients are the first to use a bacterium naturally found in the skin: Lactobacillus crispatus (L crispatus), an anaerobic Gram-positive rod bacterium that has been shown to decrease with age.
" Consumers are increasingly aware of the health benefits of biotic ingredients, whether they are pre-, pro- or post-biotic. This trend has its roots in the food industry" Cécile Kalem, BASF's head of active ingredients launch in Europe, said. " What is common practice in this field has, until now, been one of the most difficult tasks for the personal care industry: incorporating live skin bacteria into cosmetic formulations and keeping them active. With Probiolift, we have found a solution to this challenge - a true breakthrough from our research and development teams."
New insights into changes in the facial microbiome during aging
Complementing existing research that indicates that the diversity of the skin microbiota changes with age, BASF conducted a new study on the difference in facial microbiome composition between young and old people. The research team found that lactic acid bacteria, including Lactobacilli, significantly decrease in mature skin. The species L. crispatus, in particular, decreased in the subocular area and was not detectable in the wrinkle troughs of older volunteers. This finding led BASF researchers to speculate that L. crispatus, isolated from human skin, could be the key to younger-looking skin. BASF has developed two cosmetic ingredients from the same biofermentation process: Probiolift, the probiotic with dormant cells of living L. crispatus, and Postbiolift, the fermentation supernatant containing the metabolites secreted by L. crispatus.
Probiolift™ for fuller skin with a reduction in the appearance of wrinkles.
Probiolift is composed of live but dormant L. crispatus bacteria that awaken on contact with water on the skin. The ingredient thus unlocks a previously largely untapped potential in the biotic beauty sector. It promotes harmonious skin aging by giving the skin a fuller appearance and improving the appearance of forehead wrinkles.
Twenty-nine female volunteers between the ages of 45 and 65, who had wrinkles or fine lines on the forehead, participated in the clinical study. The efficacy of a base cream containing Probiolift at 0.05 % was evaluated in comparison to a placebo base cream. The Probiolift allowed the volunteers' skin to appear fuller after two months. Although the appearance of forehead wrinkles is more difficult to reduce than crow's feet, the new probiotic offered a visible correction in this area as well, allowing for a 5 % reduction in the appearance of wrinkles compared to placebo. The clinical results were supported by the biological properties of L crispatus demonstrated in advanced in vitro testing.
Postbiolift for a more elastic, smooth and uniform skin appearance
Postbiolift is a unique new postbiotic ingredient containing beneficial metabolites secreted by L. crispatus. It helps improve the mechanical properties of the skin to make it more elastic, smooth the appearance of wrinkles around the eyes and create an even skin tone.
The efficacy of Postbiolift was demonstrated in a placebo-controlled clinical study on 30 female volunteers aged 40-50 years with crow's feet wrinkles and color spots on the face. After 28 days and 56 days of treatment with the ingredient formulated at 1 % in a cream, elastic parameters were evaluated. The results were significant compared to placebo, with an improvement of up to 10 percent.
In addition, at the end of the 56-day study, Postbiolift had significantly reduced the appearance of crow's feet and pigmented age spots in these middle-aged women by nearly 7 % compared to placebo. The mechanism behind the observed clinical results was demonstrated in comprehensive in vitro studies.
Together, these two new ingredients allow cosmetic manufacturers to meet the growing demand for clinically proven, youthful skin biotics.
